Abstract
We report a concise post-modification method to convert an electroneutral triazole-linked DNA (TLDNA) to a positively charged triazolium-linked analogue, TLDNA+. A one-step methylation of oligothymine TLDNA successfully afforded TLDNA+ with a dramatic improvement in the solubility. The pentameric oligothymine TLDNA+ formed a stable triple helix with natural oligoadenine DNA as well as a mercury-mediated self-duplex.
Original language | English |
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Pages (from-to) | 1023-1028 |
Number of pages | 6 |
Journal | Heterocycles |
Volume | 87 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2013 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry