Post-modification of triazole-linked analogues of dna for positively charged variants

Tomoko Fujino, Yusuke Miyauchi, Nobuhide Tsunaka, Koudai Okada, Hiroyuki Isobe

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We report a concise post-modification method to convert an electroneutral triazole-linked DNA (TLDNA) to a positively charged triazolium-linked analogue, TLDNA+. A one-step methylation of oligothymine TLDNA successfully afforded TLDNA+ with a dramatic improvement in the solubility. The pentameric oligothymine TLDNA+ formed a stable triple helix with natural oligoadenine DNA as well as a mercury-mediated self-duplex.

Original languageEnglish
Pages (from-to)1023-1028
Number of pages6
JournalHeterocycles
Volume87
Issue number5
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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