Possible role of autophagy in the treatment of pancreatic cancer with histone deacetylase inhibitors

Hidemi Rikiishi

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer.

Original languageEnglish
Pages (from-to)2026-2043
Number of pages18
JournalCancers
Volume2
Issue number4
DOIs
Publication statusPublished - 2010 Dec

Keywords

  • Apoptosis
  • Autophagy
  • ER stress
  • Epigenetics
  • Histone deacetylase
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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