Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype

Takamitsu Sasaki, Miho Horikawa, Kazuhiko Orikasa, Makoto Sato, Yoichi Arai, Yoshitaka Mitachi, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine. CYP4B1 allelic variants CYP4B1*1-*7 were recently identified. We thus hypothesized that CYP4B1 genotypes may modify bladder cancer risk. We examined the CYP4B1 genotypes in 169 bladder cancer cases and 190 hospital controls using a hybridization probe assay. Among the CYP4B1 genotypes observed, the most frequent genotypes in both the groups were CYP4B1*1/*1, *1/*2, *1/*3 and *2/*2. Logistic regression analysis revealed that the subjects carrying the CYP4B1*1/*2 or *2/*2 genotypes had a 1.75-fold increased risk of bladder cancer (95% CI=1.03-2.95, P = 0.038) compared with the subjects carrying the CYP4B1*1/*1 genotype. We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer.

Original languageEnglish
Pages (from-to)634-640
Number of pages7
JournalJapanese journal of clinical oncology
Volume38
Issue number9
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Bladder cancer
  • CYP4B1
  • Genotype

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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