Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs

Masayuki Asano, Hiroshi Inoue, Masakazu Ichinose, Shinji Okada, Tamotsu Takishima

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

To elucidate the mechanism of airway hyperrcsponsiveness after late asthmatic response (LAR), we analyzed bronchoalveolar lavage fluid (BALF) and examined the airway smooth muscle contractility to acetylcholine (ACh). On day 1 after LAR, there was a significant positive correlation between the number of neutrophils in BALF and the increase in airway responsiveness after LAR (r = 0.82, p < 0.01). In the in vitro study, the dose response curve to ACh was significantly shifted to the left after removal of the epithelium in control guinea pigs. However, in hyperresponsive animals after LAR, removal of the epithelium had no significant effect on ACh-induced response. These results indicate that infiltration of neutrophils and other inflammatory cells inducc epithelial damage and hence the development of airway hyperrcsponsiveness after LAR.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalInternational archives of allergy and immunology
Volume103
Issue number1
DOIs
Publication statusPublished - 1994

Keywords

  • Airway hyperresponsiveness
  • Epithelium
  • Late asthmatic response
  • Neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs'. Together they form a unique fingerprint.

Cite this