Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs

Masayuki Asano; Hiroshi Inoue; Masakazu Ichinose; Shinji Okada; Tamotsu Takishima

doi:10.1159/000236610

Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs

Masayuki Asano, Hiroshi Inoue, Masakazu Ichinose, Shinji Okada, Tamotsu Takishima

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

To elucidate the mechanism of airway hyperrcsponsiveness after late asthmatic response (LAR), we analyzed bronchoalveolar lavage fluid (BALF) and examined the airway smooth muscle contractility to acetylcholine (ACh). On day 1 after LAR, there was a significant positive correlation between the number of neutrophils in BALF and the increase in airway responsiveness after LAR (r = 0.82, p < 0.01). In the in vitro study, the dose response curve to ACh was significantly shifted to the left after removal of the epithelium in control guinea pigs. However, in hyperresponsive animals after LAR, removal of the epithelium had no significant effect on ACh-induced response. These results indicate that infiltration of neutrophils and other inflammatory cells inducc epithelial damage and hence the development of airway hyperrcsponsiveness after LAR.

Original language	English
Pages (from-to)	88-94
Number of pages	7
Journal	International archives of allergy and immunology
Volume	103
Issue number	1
DOIs	https://doi.org/10.1159/000236610
Publication status	Published - 1994

Keywords

Airway hyperresponsiveness
Epithelium
Late asthmatic response
Neutrophils

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1159/000236610

Fingerprint Dive into the research topics of 'Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs'. Together they form a unique fingerprint.

Cite this

@article{d91d8ee0fc6b46c68b1a5eabafbc96d5,

title = "Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs",

abstract = "To elucidate the mechanism of airway hyperrcsponsiveness after late asthmatic response (LAR), we analyzed bronchoalveolar lavage fluid (BALF) and examined the airway smooth muscle contractility to acetylcholine (ACh). On day 1 after LAR, there was a significant positive correlation between the number of neutrophils in BALF and the increase in airway responsiveness after LAR (r = 0.82, p < 0.01). In the in vitro study, the dose response curve to ACh was significantly shifted to the left after removal of the epithelium in control guinea pigs. However, in hyperresponsive animals after LAR, removal of the epithelium had no significant effect on ACh-induced response. These results indicate that infiltration of neutrophils and other inflammatory cells inducc epithelial damage and hence the development of airway hyperrcsponsiveness after LAR.",

keywords = "Airway hyperresponsiveness, Epithelium, Late asthmatic response, Neutrophils",

author = "Masayuki Asano and Hiroshi Inoue and Masakazu Ichinose and Shinji Okada and Tamotsu Takishima",

year = "1994",

doi = "10.1159/000236610",

language = "English",

volume = "103",

pages = "88--94",

journal = "International Archives of Allergy and Immunology",

issn = "1018-2438",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs

AU - Asano, Masayuki

AU - Inoue, Hiroshi

AU - Ichinose, Masakazu

AU - Okada, Shinji

AU - Takishima, Tamotsu

PY - 1994

Y1 - 1994

N2 - To elucidate the mechanism of airway hyperrcsponsiveness after late asthmatic response (LAR), we analyzed bronchoalveolar lavage fluid (BALF) and examined the airway smooth muscle contractility to acetylcholine (ACh). On day 1 after LAR, there was a significant positive correlation between the number of neutrophils in BALF and the increase in airway responsiveness after LAR (r = 0.82, p < 0.01). In the in vitro study, the dose response curve to ACh was significantly shifted to the left after removal of the epithelium in control guinea pigs. However, in hyperresponsive animals after LAR, removal of the epithelium had no significant effect on ACh-induced response. These results indicate that infiltration of neutrophils and other inflammatory cells inducc epithelial damage and hence the development of airway hyperrcsponsiveness after LAR.

AB - To elucidate the mechanism of airway hyperrcsponsiveness after late asthmatic response (LAR), we analyzed bronchoalveolar lavage fluid (BALF) and examined the airway smooth muscle contractility to acetylcholine (ACh). On day 1 after LAR, there was a significant positive correlation between the number of neutrophils in BALF and the increase in airway responsiveness after LAR (r = 0.82, p < 0.01). In the in vitro study, the dose response curve to ACh was significantly shifted to the left after removal of the epithelium in control guinea pigs. However, in hyperresponsive animals after LAR, removal of the epithelium had no significant effect on ACh-induced response. These results indicate that infiltration of neutrophils and other inflammatory cells inducc epithelial damage and hence the development of airway hyperrcsponsiveness after LAR.

KW - Airway hyperresponsiveness

KW - Epithelium

KW - Late asthmatic response

KW - Neutrophils

UR - http://www.scopus.com/inward/record.url?scp=0028156803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028156803&partnerID=8YFLogxK

U2 - 10.1159/000236610

DO - 10.1159/000236610

M3 - Article

C2 - 8260855

AN - SCOPUS:0028156803

VL - 103

SP - 88

EP - 94

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 1

ER -