Possibility for tumor detection with fatty acid analogs

Kazuo Kubota, Toshihiro Takahashi, Takehiko Fujiwara, Susumu Yamada, Tachio Sato, Roko Kubota, Ren Iwata, Kiichi Ishiwata, Tatsuo Ido, Taiju Matsuzawa

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Newly synthesized 17-[18F]fluoro-3-methylheptadecanoic acid ([18F]BMHDA), 16-[18F]fluoropalmitic acid ([18F]PA) and 15-(p-[125I]iodophenyl)-3-R,S-methylpentadecanoic acid ([125I]BMIPP), fatty acid tracers, were examined for the possibility of tumor imaging using 10 tumor models in rats and mice. The highest tumor/muscle ratios with [18F]BMHDA were 2.3 using rat tumor AH109A and 1.9 using mouse tumor B16F1 (tumor accumulation 0.41 ± 0.05, 4.29 ± 0.77% ID/g, respectively). Tumor/muscle ratios with [125I]BMIPP and [18F]PA were lower than those with [18F]BMHDA. Labeled fatty acids seem to have a lower potential for tumor detection.

    Original languageEnglish
    Pages (from-to)191-195
    Number of pages5
    JournalInternational Journal of Radiation Applications and Instrumentation.
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - 1991

    ASJC Scopus subject areas

    • Medicine(all)

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