Positron emission tomography study of the alterations in brain distribution of [11C]methamphetamine in methamphetamine-sensitized dog

Hitoshi Nakamura; Takanori Hishinuma; Yoshihisa Tomioka; Tatsuo Ido; Ren Iwata; Yoshihito Funaki; Masatoshi Itoh; Takehiko Fujiwara; Kazuhiko Yanai; Mitsumoto Sato; Yohtaro Numachi; Sumiko Yoshida; Michinao Mizugaki

doi:10.1111/j.1749-6632.1996.tb17462.x

Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog

Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Takehiko Fujiwara, Kazuhiko Yanai, Mitsumoto Sato, Yohtaro Numachi, Sumiko Yoshida, Michinao Mizugaki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We newly prepared a MAP-sensitized dog by repeated MAP treatment and studied the brain distribution of [¹¹C]MAP in the normal and the MAP-sensitized dog using PET. The maximal level of accumulation of [¹¹C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [¹¹C]MAP in the MAP-sensitized brain indicates that subchronic MAP administration causes some functional change in the uptake site of MAP. The pharmacokinetic change may, in part, account for behavioral sensitization.

Original language	English
Pages (from-to)	401-408
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	801
DOIs	https://doi.org/10.1111/j.1749-6632.1996.tb17462.x
Publication status	Published - 1996

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.1996.tb17462.x

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Nakamura, H., Hishinuma, T., Tomioka, Y., Ido, T., Iwata, R., Funaki, Y., Itoh, M., Fujiwara, T., Yanai, K., Sato, M., Numachi, Y., Yoshida, S., & Mizugaki, M. (1996). Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog. Annals of the New York Academy of Sciences, 801, 401-408. https://doi.org/10.1111/j.1749-6632.1996.tb17462.x

Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog. / Nakamura, Hitoshi; Hishinuma, Takanori; Tomioka, Yoshihisa; Ido, Tatsuo; Iwata, Ren; Funaki, Yoshihito ; Itoh, Masatoshi; Fujiwara, Takehiko; Yanai, Kazuhiko; Sato, Mitsumoto; Numachi, Yohtaro; Yoshida, Sumiko; Mizugaki, Michinao.

In: Annals of the New York Academy of Sciences, Vol. 801, 1996, p. 401-408.

Research output: Contribution to journal › Article › peer-review

Nakamura, H, Hishinuma, T, Tomioka, Y, Ido, T, Iwata, R, Funaki, Y , Itoh, M, Fujiwara, T, Yanai, K, Sato, M, Numachi, Y, Yoshida, S & Mizugaki, M 1996, 'Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog', Annals of the New York Academy of Sciences, vol. 801, pp. 401-408. https://doi.org/10.1111/j.1749-6632.1996.tb17462.x

Nakamura, Hitoshi ; Hishinuma, Takanori ; Tomioka, Yoshihisa ; Ido, Tatsuo ; Iwata, Ren ; Funaki, Yoshihito ; Itoh, Masatoshi ; Fujiwara, Takehiko ; Yanai, Kazuhiko ; Sato, Mitsumoto ; Numachi, Yohtaro ; Yoshida, Sumiko ; Mizugaki, Michinao. / Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog. In: Annals of the New York Academy of Sciences. 1996 ; Vol. 801. pp. 401-408.

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abstract = "We newly prepared a MAP-sensitized dog by repeated MAP treatment and studied the brain distribution of [11C]MAP in the normal and the MAP-sensitized dog using PET. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [11C]MAP in the MAP-sensitized brain indicates that subchronic MAP administration causes some functional change in the uptake site of MAP. The pharmacokinetic change may, in part, account for behavioral sensitization.",

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AU - Tomioka, Yoshihisa

AU - Ido, Tatsuo

AU - Iwata, Ren

AU - Funaki, Yoshihito

AU - Itoh, Masatoshi

AU - Fujiwara, Takehiko

AU - Yanai, Kazuhiko

AU - Sato, Mitsumoto

AU - Numachi, Yohtaro

AU - Yoshida, Sumiko

AU - Mizugaki, Michinao

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Positron emission tomography study of the alterations in brain distribution of [¹¹C]methamphetamine in methamphetamine-sensitized dog

Abstract

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