TY - JOUR
T1 - Positron emission tomography study of the alterations in brain distribution of [11C]methamphetamine in methamphetamine-sensitized dog
AU - Nakamura, Hitoshi
AU - Hishinuma, Takanori
AU - Tomioka, Yoshihisa
AU - Ido, Tatsuo
AU - Iwata, Ren
AU - Funaki, Yoshihito
AU - Itoh, Masatoshi
AU - Fujiwara, Takehiko
AU - Yanai, Kazuhiko
AU - Sato, Mitsumoto
AU - Numachi, Yohtaro
AU - Yoshida, Sumiko
AU - Mizugaki, Michinao
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We newly prepared a MAP-sensitized dog by repeated MAP treatment and studied the brain distribution of [11C]MAP in the normal and the MAP-sensitized dog using PET. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [11C]MAP in the MAP-sensitized brain indicates that subchronic MAP administration causes some functional change in the uptake site of MAP. The pharmacokinetic change may, in part, account for behavioral sensitization.
AB - We newly prepared a MAP-sensitized dog by repeated MAP treatment and studied the brain distribution of [11C]MAP in the normal and the MAP-sensitized dog using PET. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [11C]MAP in the MAP-sensitized brain indicates that subchronic MAP administration causes some functional change in the uptake site of MAP. The pharmacokinetic change may, in part, account for behavioral sensitization.
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U2 - 10.1111/j.1749-6632.1996.tb17462.x
DO - 10.1111/j.1749-6632.1996.tb17462.x
M3 - Article
C2 - 8959054
AN - SCOPUS:0030462933
VL - 801
SP - 401
EP - 408
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -