Positron emission tomography (PET) study of the alterations in brain distribution of [11C]methamphetamine in methamphetamine sensitized dog

Michinao Mizugaki, Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Shunji Ishiwata, Hideaki Suzuki, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Takehiko Fujiwara, Kazuhiko Yanai, Mitsumoto Sato, Yohtaro Numachi, Sumiko Yoshida

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

[11C]Methamphetamine ([11C]MAP) was synthesized by an automated on-line [11C]methylation system for positron emission tomography (PET) study. We newly produced a MAP sensitized dog by repeated MAP treatment and studied the brain distribution of [11C]MAP in the normal and the MAP sensitized dog. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [11C]MAP in the MAP sensitized brain indicates that subchronic MAP administration causes some functional change in uptake site of MAP.

Original languageEnglish
Pages (from-to)803-807
Number of pages5
JournalNuclear Medicine and Biology
Volume22
Issue number6
DOIs
Publication statusPublished - 1995 Aug

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Positron emission tomography (PET) study of the alterations in brain distribution of [<sup>11</sup>C]methamphetamine in methamphetamine sensitized dog'. Together they form a unique fingerprint.

Cite this