Positive correlations between tumor uptake on FDG PET and energy expenditure of patients with esophageal cancer

Atsushi Mitamura, Tomohiro Kaneta, Goh Miyata, Kentaro Takanami, Tomomichi Hiraide, Hiroshi Fukuda, Syouki Takahashi, Susumu Satomi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Purpose Cancer patients are prone to clinical malnutrition; moreover, the energy expenditure in patients with certain cancers is higher than that in healthy individuals, rendering their nutritional management a challenging issue. We hypothesized that 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake on positron emission tomography (PET) may be related to the energy expenditure and analyzed the FDG uptake and energy expenditure in esophageal cancer patients to clarify this. Methods Esophageal cancer patients [n = 13, 10 males and 3 females, age 66.5 ± 8.9 (51-82) years] were evaluated for FDG uptake using PET. The resting energy expenditure (REE) and basal energy expenditure (BEE) were calculated using indirect calorimetry and the Harris- Benedict formula, respectively. Regression analyses were performed to compare the parameters of imaging and energy expenditure. Results Positive correlations were found between tumor uptake on FDG PET and the parameters of energy expenditure. Among them, the correlations between SUVmax and the ratio of REE to BEE (REE/BEE, r = 0.59; p = 0.035) and between SUVmax and the difference between REE and BEE (REE - BEE, r = 0.58; p = 0.036) were moderate and statistically significant. Further, the correlation between tumor uptake expressed as a percentage (%TU) and REE/BEE was mild (r = 0.51) but not significant (p = 0.07), while that between %TU and REE-BEE was weak (r = 0.42) and not significant (p = 0.15). Conclusion Significant positive correlations between SUVmax on FDG PET and energy expenditure were noted in our study; we consider that these results may aid in determining the nutritional management for esophagealcancer patients.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalAnnals of Nuclear Medicine
Volume25
Issue number4
DOIs
Publication statusPublished - 2011 May 1

Keywords

  • Energy expenditure
  • Esophageal cancer
  • Keywords FDG PET
  • Nutrition

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Positive correlations between tumor uptake on FDG PET and energy expenditure of patients with esophageal cancer'. Together they form a unique fingerprint.

Cite this