Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas

Yoshiko Kagimoto, Kenshi Yamasaki, Ryoko Shimada-Ohmori, Liu Nan, Yukikazu Numata, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1-cm in diameter, which caused severe pain diffused throughout an area of 20-cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma.

Original languageEnglish
Pages (from-to)690-694
Number of pages5
JournalJournal of Dermatology
Issue number6
Publication statusPublished - 2017 Jun


  • PGE2
  • VR1
  • algogenic substance
  • leiomyoma

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas'. Together they form a unique fingerprint.

Cite this