Porous polymer microneedles with interconnecting microchannels for rapid fluid transport

Liming Liu, Hiroyuki Kai, Kuniaki Nagamine, Yudai Ogawa, Matsuhiko Nishizawa

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

A porous polymer microneedle array with an average pore diameter of ∼1 μm was fabricated by photopolymerization of an acrylate monomer in the presence of a porogen within a mold. Porosity measurement and water absorption testing revealed that the pores are interconnected throughout the microneedle, which enabled rapid wetting of the microneedle by capillary action. The porosity of the polymer microneedles can be modulated by varying porogen content, and this allowed balancing fast water absorption speed and sufficient mechanical strength to penetrate a skin. The developed porous polymer microneedle array is a potentially versatile tool for rapid fluid transport from and into a body through the skin.

Original languageEnglish
Pages (from-to)48630-48635
Number of pages6
JournalRSC Advances
Volume6
Issue number54
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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