Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang; Xuetao Shi; Li Ren; Chunming Wang; Dong An Wang

doi:10.1016/j.msec.2009.07.018

Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang, Xuetao Shi, Li Ren, Chunming Wang, Dong An Wang

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

Original language	English
Pages (from-to)	2502-2507
Number of pages	6
Journal	Materials Science and Engineering C
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.msec.2009.07.018
Publication status	Published - 2009 Oct 15

Keywords

Microsphere
Poly (lactic-co-glycolide)
Porous
Scaffold

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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Cite this

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title = "Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications",

abstract = "In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.",

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AU - Shi, Xuetao

AU - Ren, Li

AU - Wang, Chunming

AU - Wang, Dong An

PY - 2009/10/15

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