Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang, Xuetao Shi, Li Ren, Chunming Wang, Dong An Wang

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

Original languageEnglish
Pages (from-to)2502-2507
Number of pages6
JournalMaterials Science and Engineering C
Volume29
Issue number8
DOIs
Publication statusPublished - 2009 Oct 15
Externally publishedYes

Keywords

  • Microsphere
  • Poly (lactic-co-glycolide)
  • Porous
  • Scaffold

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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