Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang; Xuetao Shi; Li Ren; Chunming Wang; Dong An Wang

doi:10.1016/j.msec.2009.07.018

Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang, Xuetao Shi, Li Ren, Chunming Wang, Dong An Wang

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

Original language	English
Pages (from-to)	2502-2507
Number of pages	6
Journal	Materials Science and Engineering C
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.msec.2009.07.018
Publication status	Published - 2009 Oct 15

Keywords

Microsphere
Poly (lactic-co-glycolide)
Porous
Scaffold

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.msec.2009.07.018

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title = "Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications",

abstract = "In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.",

keywords = "Microsphere, Poly (lactic-co-glycolide), Porous, Scaffold",

author = "Yingjun Wang and Xuetao Shi and Li Ren and Chunming Wang and Wang, {Dong An}",

note = "Funding Information: Shi Xuetao is a China Scholarship Council (CSC) scholarship recipient (2007U33046). This research was supported by the National Natural Science Foundation of China (Grant 50572029 , 50732003 , 50830101 , U0834003 , and 50803018 ), National Basic Research Program of China (Grant No: 2005CB623902 ), National Science and Technology Support Programme of China (Grant No. 2006BAI16B04 ), and Natural Science Foundation of Guangdong, China (Grant No. 4205786 ). The research was also AcRF Tier 1 RG 64/08, Ministry of Education, Singapore.",

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doi = "10.1016/j.msec.2009.07.018",

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AU - Wang, Yingjun

AU - Shi, Xuetao

AU - Ren, Li

AU - Wang, Chunming

AU - Wang, Dong An

N1 - Funding Information: Shi Xuetao is a China Scholarship Council (CSC) scholarship recipient (2007U33046). This research was supported by the National Natural Science Foundation of China (Grant 50572029 , 50732003 , 50830101 , U0834003 , and 50803018 ), National Basic Research Program of China (Grant No: 2005CB623902 ), National Science and Technology Support Programme of China (Grant No. 2006BAI16B04 ), and Natural Science Foundation of Guangdong, China (Grant No. 4205786 ). The research was also AcRF Tier 1 RG 64/08, Ministry of Education, Singapore.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

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KW - Poly (lactic-co-glycolide)

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KW - Scaffold

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Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

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Keywords

ASJC Scopus subject areas

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