TY - JOUR
T1 - Polyunsaturated fatty acid levels of serum and red blood cells in apparently healthy Japanese subjects living in an Urban Area
AU - Yanagisawa, Naotake
AU - Shimada, Kazunori
AU - Miyazaki, Tetsuro
AU - Kume, Atsumi
AU - Kitamura, Yohei
AU - Ichikawa, Ryoko
AU - Ohmura, Hirotoshi
AU - Kiyanagi, Takashi
AU - Hiki, Makoto
AU - Fukao, Kosuke
AU - Sumiyoshi, Katsuhiko
AU - Hirose, Kuniaki
AU - Matsumori, Rie
AU - Takizawa, Hirotaka
AU - Fujii, Kiyotaka
AU - Mokuno, Hiroshi
AU - Inoue, Nao
AU - Daida, Hiroyuki
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Aim: We assessed levels of polyunsaturated fatty acid (PUFA) in serum and red blood cells (RBCs) among groups stratified by generation and its clinical significance in Japanese subjects living in an urban area. Methods: We enrolled 200 apparently healthy Japanese (126 males, mean age: 50.3±9.2 years) living in an urban area. Levels of PUFA, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) in serum and RBCs were measured for each generation (G1 <35y, G2 35y-<45y, G3 45y-<55y, G4 55y-<65y, G5 ≥65y). Results: No significant differences in EPA, DHA, AA, or EPA/AA were observed between males and females. After dividing into generations, stepwise increases in EPA and DHA, but not DGLA or AA, were observed in serum (all p<0.0001). EPA/AA ratios were stepwisely increased in serum (mean: G1:0.26, G2:0.29, G3:0.43, G4:0.58, G5:0.68, p<0.0001) and RBCs (mean: G1:0.10, G2:0.09, G3:0.15, G4:0.20, G5:0.23, p<0.0001). Positive correlations of EPA (r = 0.83), DHA (r = 0.55), DGLA (r = 0.54), AA (r = 0.29), and EPA/AA (r = 0.91) were demonstrated between serum and RBCs. In addition, a significant positive correlation between EPA/AA ratios and insulin sensitivity as well as a negative correlation between those ratios and insulin resistance were observed in subjects with metabolic syndrome. Conclusion: Low levels of EPA/AA, which were associated with insulin resistance, were demonstrated in young Japanese adults living in an urban area.
AB - Aim: We assessed levels of polyunsaturated fatty acid (PUFA) in serum and red blood cells (RBCs) among groups stratified by generation and its clinical significance in Japanese subjects living in an urban area. Methods: We enrolled 200 apparently healthy Japanese (126 males, mean age: 50.3±9.2 years) living in an urban area. Levels of PUFA, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) in serum and RBCs were measured for each generation (G1 <35y, G2 35y-<45y, G3 45y-<55y, G4 55y-<65y, G5 ≥65y). Results: No significant differences in EPA, DHA, AA, or EPA/AA were observed between males and females. After dividing into generations, stepwise increases in EPA and DHA, but not DGLA or AA, were observed in serum (all p<0.0001). EPA/AA ratios were stepwisely increased in serum (mean: G1:0.26, G2:0.29, G3:0.43, G4:0.58, G5:0.68, p<0.0001) and RBCs (mean: G1:0.10, G2:0.09, G3:0.15, G4:0.20, G5:0.23, p<0.0001). Positive correlations of EPA (r = 0.83), DHA (r = 0.55), DGLA (r = 0.54), AA (r = 0.29), and EPA/AA (r = 0.91) were demonstrated between serum and RBCs. In addition, a significant positive correlation between EPA/AA ratios and insulin sensitivity as well as a negative correlation between those ratios and insulin resistance were observed in subjects with metabolic syndrome. Conclusion: Low levels of EPA/AA, which were associated with insulin resistance, were demonstrated in young Japanese adults living in an urban area.
KW - Arachidonic acid
KW - EPA/AA ratio
KW - Eicosapentaenoic acid
KW - Japanese population
KW - Risk factor
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U2 - 10.5551/jat.2618
DO - 10.5551/jat.2618
M3 - Article
C2 - 20228612
AN - SCOPUS:77951201860
VL - 17
SP - 285
EP - 294
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 3
ER -