Polysaccharide (ank-102) from polianthes tuberosa cells deteriorates the resistance of mice to listeria monocytogenes infection

Toshiro Majima; Kazuya Otsuji; Ryoichi Nagatomi; Tasuke Konno

doi:10.3109/08923979509052720

Polysaccharide (ank-102) from polianthes tuberosa cells deteriorates the resistance of mice to listeria monocytogenes infection

Toshiro Majima, Kazuya Otsuji, Ryoichi Nagatomi, Tasuke Konno

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.

Original language	English
Pages (from-to)	59-68
Number of pages	10
Journal	Immunopharmacology and Immunotoxicology
Volume	17
Issue number	1
DOIs	https://doi.org/10.3109/08923979509052720
Publication status	Published - 1995 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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abstract = "Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.",

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AU - Nagatomi, Ryoichi

AU - Konno, Tasuke

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Polysaccharide (ank-102) from polianthes tuberosa cells deteriorates the resistance of mice to listeria monocytogenes infection

Abstract

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