Polysaccharide (ank-102) from polianthes tuberosa cells deteriorates the resistance of mice to listeria monocytogenes infection

Toshiro Majima, Kazuya Otsuji, Ryoichi Nagatomi, Tasuke Konno

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalImmunopharmacology and Immunotoxicology
Volume17
Issue number1
DOIs
Publication statusPublished - 1995 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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