Polymorphisms of human Ah receptor gene are not involved in lung cancer

Kaname Kawajiri, Junko Watanabe, Hidetaka Eguchi, Kei Nakachi, Chikako Kiyohara, Shin Ichi Hayashi

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The Ah receptor (Ahr) is a ligand-dependent transcription factor that positively regulates inducible expression of the CYP1A1 gene. Based on the sequence information of the human Ahr and the intron-exon junctions of the mouse counterpart, an analysis of single-strand conformational polymorphism (SSCP) was carried out to detect subtle base differences in the coding region of the gene among individuals. We found that the Ahr protein has at least two forms of variants in a Japanese gene pool, and that these variants can be ascribed to one amino acid replacement of Arg by Lys at codon 554. The frequencies of Arg-coded and Lyscoded alleles were 0.57 and 0.43, respectively. We found, however, that this germ line polymorphism of the Ahr gene did not show a significant association with aryl hydrocarbon hydroxylase (AHH) inducibility nor with lung cancer incidence.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalPharmacogenetics
Volume5
Issue number3
DOIs
Publication statusPublished - 1995 Jun
Externally publishedYes

Keywords

  • AHH
  • Ahr
  • Genetic polymorphism
  • Lung cancer

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Polymorphisms of human Ah receptor gene are not involved in lung cancer'. Together they form a unique fingerprint.

  • Cite this