Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Akemi Hosoda; Takashi Inoue; Chang C. Mao; Young Hee Jeong; Azumi Yamagishi; Mingjuan Ye; Tokuo Yamamoto; Dong Ho Kim; Shigeru Saeki

doi:10.1271/bbb.90857

Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Akemi Hosoda, Takashi Inoue, Chang C. Mao, Young Hee Jeong, Azumi Yamagishi, Mingjuan Ye, Tokuo Yamamoto, Dong Ho Kim, Shigeru Saeki

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

Original language	English
Pages (from-to)	677-679
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	3
DOIs	https://doi.org/10.1271/bbb.90857
Publication status	Published - 2010

Keywords

Alzheimer's disease
ApoE receptor 2
Polymorphisms

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.90857

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Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients. / Hosoda, Akemi; Inoue, Takashi; Mao, Chang C.; Jeong, Young Hee; Yamagishi, Azumi; Ye, Mingjuan; Yamamoto, Tokuo; Kim, Dong Ho; Saeki, Shigeru.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 3, 2010, p. 677-679.

Research output: Contribution to journal › Article › peer-review

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title = "Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients",

abstract = "Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.",

keywords = "Alzheimer's disease, ApoE receptor 2, Polymorphisms",

author = "Akemi Hosoda and Takashi Inoue and Mao, {Chang C.} and Jeong, {Young Hee} and Azumi Yamagishi and Mingjuan Ye and Tokuo Yamamoto and Kim, {Dong Ho} and Shigeru Saeki",

note = "Funding Information: We thank Dr. S. Tsuji, Graduate School of Medicine, University of Tokyo and Dr. K. Okuizumi, Brain Research Institute, Niigata University. This research was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of the Ministry of Health and Welfare of Japan and the Uehara Memorial Foundation.",

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doi = "10.1271/bbb.90857",

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T1 - Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

AU - Hosoda, Akemi

AU - Inoue, Takashi

AU - Mao, Chang C.

AU - Jeong, Young Hee

AU - Yamagishi, Azumi

AU - Ye, Mingjuan

AU - Yamamoto, Tokuo

AU - Kim, Dong Ho

AU - Saeki, Shigeru

N1 - Funding Information: We thank Dr. S. Tsuji, Graduate School of Medicine, University of Tokyo and Dr. K. Okuizumi, Brain Research Institute, Niigata University. This research was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of the Ministry of Health and Welfare of Japan and the Uehara Memorial Foundation.

PY - 2010

Y1 - 2010

N2 - Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

AB - Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

KW - Alzheimer's disease

KW - ApoE receptor 2

KW - Polymorphisms

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Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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