Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Akemi Hosoda, Takashi Inoue, Chang C. Mao, Young Hee Jeong, Azumi Yamagishi, Mingjuan Ye, Tokuo Yamamoto, Dong Ho Kim, Shigeru Saeki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

Original languageEnglish
Pages (from-to)677-679
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number3
DOIs
Publication statusPublished - 2010 Apr 1

Keywords

  • Alzheimer's disease
  • ApoE receptor 2
  • Polymorphisms

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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