Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Akemi Hosoda; Takashi Inoue; Chang C. Mao; Young Hee Jeong; Azumi Yamagishi; Mingjuan Ye; Tokuo Yamamoto; Dong Ho Kim; Shigeru Saeki

doi:10.1271/bbb.90857

Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients

Akemi Hosoda, Takashi Inoue, Chang C. Mao, Young Hee Jeong, Azumi Yamagishi, Mingjuan Ye, Tokuo Yamamoto, Dong Ho Kim, Shigeru Saeki

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

Original language	English
Pages (from-to)	677-679
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	3
DOIs	https://doi.org/10.1271/bbb.90857
Publication status	Published - 2010 Apr 1

Keywords

Alzheimer's disease
ApoE receptor 2
Polymorphisms

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Polymorphisms in the human apolipoprotein e receptor 2 gene in Japanese sporadic alzheimer's disease patients. / Hosoda, Akemi; Inoue, Takashi; Mao, Chang C.; Jeong, Young Hee; Yamagishi, Azumi; Ye, Mingjuan; Yamamoto, Tokuo; Kim, Dong Ho; Saeki, Shigeru.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 3, 01.04.2010, p. 677-679.

Research output: Contribution to journal › Article › peer-review

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abstract = "Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.",

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AU - Kim, Dong Ho

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