Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice

Kenta Teruya, Ayumi Oguma, Keita Arai, Keiko Nishizawa, Sara Iwabuchi, Miki Watanabe-Matsui, Yuji Sakasegawa, Hermann Schätzl, Sabine Gilch, Katsumi Doh-ura

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalBiochemical and biophysical research communications
Volume560
DOIs
Publication statusPublished - 2021 Jun 30

Keywords

  • Cellulose ether
  • Genetic analysis
  • Glia maturation factor
  • Prion
  • Proportional hazards model
  • Proteomics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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