Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects

Motoko Maekawa, Yoshimi Iwayama, Ryoichi Arai, Kazuhiko Nakamura, Tetsuo Ohnishi, Tomoko Toyota, Masatsugu Tsujii, Yuji Okazaki, Noriko Osumi, Yuji Owada, Norio Mori, Takeo Yoshikawa

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23 Citations (Scopus)

Abstract

Fatty acid-binding protein (FABP) gene family encode fatty acid-binding proteins and consist of at least 12 members, of which FABP7, 5 and 3 are expressed in the brain. We previously showed that FABP7 is associated with schizophrenia and bipolar disorder. Recently, genetic overlap between autism and schizophrenia has been reported. Therefore, in this study, we set out to examine the possible roles of brain-expressed FABPs in autism, focusing primarily on potentially functional polymorphisms (that is, missense polymorphisms). First, we resequenced the three genes using 285 autism samples. We identified 13 polymorphisms, of which 7 are novel. Of the novel single-nucleotide polymorphisms (SNPs), two are missense mutations, namely, 376G>C (Val126Leu) in FABP7 and 340G>C (Gly114Arg) in FABP5. Second, we tested for the genetic association of four missense SNPs with autism and schizophrenia, but failed to detect significant results. Finally, as a web-based algorithm predicts that the 8A>G (Asp3Gly; rs17848124) in FABP3 is 'probably damaging', we estimated the possible impact of this SNP, and found that the loss of charge and salt bridge, caused by the Asp3-to-Gly3, may affect stability of the FABP3 protein. Future searches for associated phenotypes with missense SNPs using larger samples are highly warranted.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalJournal of Human Genetics
Volume55
Issue number2
DOIs
Publication statusPublished - 2010 Feb

Keywords

  • Crystallographic analysis
  • Fatty acid-binding protein
  • Missense mutation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Maekawa, M., Iwayama, Y., Arai, R., Nakamura, K., Ohnishi, T., Toyota, T., Tsujii, M., Okazaki, Y., Osumi, N., Owada, Y., Mori, N., & Yoshikawa, T. (2010). Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. Journal of Human Genetics, 55(2), 127-130. https://doi.org/10.1038/jhg.2009.133