Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study

Wenxiang Quan, Minoru Yasuda, Mamoru Hashimoto, Yasuji Yamamoto, Kazunari Ishii, Hiroaki Kazui, Etsuro Mori, Tatsuya Kakigi, Kiyoshi Maeda

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7 Citations (Scopus)

Abstract

Objective: presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin-2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study. Methods: We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. Results: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E ε4 allele. Conclusions: Our results fail to support an association of presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of the neurological sciences
Volume240
Issue number1-2
DOIs
Publication statusPublished - 2006 Jan 15

Keywords

  • Alzheimer's disease
  • Case-control study
  • Polymorphism
  • Regulatory region
  • presenilin-2

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Quan, W., Yasuda, M., Hashimoto, M., Yamamoto, Y., Ishii, K., Kazui, H., Mori, E., Kakigi, T., & Maeda, K. (2006). Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study. Journal of the neurological sciences, 240(1-2), 71-75. https://doi.org/10.1016/j.jns.2005.09.004