Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease

Kazunobu Ouchi, Yoichi Suzuki, Taro Shirakawa, Fumio Kishi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Since its first description in Japan >30 years ago, Kawasaki disease (KD) has been reported worldwide. Although an infectious etiology is suspected based on the epidemiology and clinical features, a causative agent has not been identified. The disease is more frequent in children of Japanese ancestry, and siblings of children with KD have a significantly greater risk of developing KD than do children of the same age in the general population. This suggests a possible genetic susceptibility to KD. Results of this study showed that allele 1 of the 5′ promoter (GT)n repeat in the SLC11A1 (formerly NRAMP1) gene, which endows the gene with a weak promoter activity, was highly represented in patients with KD. This suggests possible explanations for both the infectious etiology of this disease and the genetic risk in the Japanese population.

Original languageEnglish
Pages (from-to)326-329
Number of pages4
JournalJournal of Infectious Diseases
Volume187
Issue number2
DOIs
Publication statusPublished - 2003 Jan 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease'. Together they form a unique fingerprint.

  • Cite this