Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases

Yutaka Fujiwara; Kouji Yamaguchi; Yuji Tanaka; Hiroaki Tomita; Yoshihiko Shiro; Kenichi Kashihara; Keiko Sato; Shigetoshi Kuroda

doi:10.1159/000113436

Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases

Yutaka Fujiwara, Kouji Yamaguchi, Yuji Tanaka, Hiroaki Tomita, Yoshihiko Shiro, Kenichi Kashihara, Keiko Sato, Shigetoshi Kuroda

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The advances made in studies on the molecular biology of the dopamine transporter (DAT) and receptors (Dl, D2, D3, D4 and D5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. Data from four studies on the variants of the D2 receptor gene (Ser_3IIn-→Cys), BalI polymorphism in D3, 48-base repeat polymorphism in D4, and 40-base repeat polymorphism in the DAT gene in patients with schizophrenia, mood disorder, neurological disease and controls are reported.

Original language	English
Pages (from-to)	6-10
Number of pages	5
Journal	European Neurology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1159/000113436
Publication status	Published - 1997 Jan
Externally published	Yes

Keywords

DNA polymorphism
Dopamine receptor subtype
Dopamine transporter
Schizophrenia

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000113436

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AU - Fujiwara, Yutaka

AU - Yamaguchi, Kouji

AU - Tanaka, Yuji

AU - Tomita, Hiroaki

AU - Shiro, Yoshihiko

AU - Kashihara, Kenichi

AU - Sato, Keiko

AU - Kuroda, Shigetoshi

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AB - The advances made in studies on the molecular biology of the dopamine transporter (DAT) and receptors (Dl, D2, D3, D4 and D5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. Data from four studies on the variants of the D2 receptor gene (Ser3IIn-→Cys), BalI polymorphism in D3, 48-base repeat polymorphism in D4, and 40-base repeat polymorphism in the DAT gene in patients with schizophrenia, mood disorder, neurological disease and controls are reported.

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KW - Dopamine receptor subtype

KW - Dopamine transporter

KW - Schizophrenia

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Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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