Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases

Yutaka Fujiwara, Kouji Yamaguchi, Yuji Tanaka, Hiroaki Tomita, Yoshihiko Shiro, Kenichi Kashihara, Keiko Sato, Shigetoshi Kuroda

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The advances made in studies on the molecular biology of the dopamine transporter (DAT) and receptors (Dl, D2, D3, D4 and D5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. Data from four studies on the variants of the D2 receptor gene (Ser3IIn-→Cys), BalI polymorphism in D3, 48-base repeat polymorphism in D4, and 40-base repeat polymorphism in the DAT gene in patients with schizophrenia, mood disorder, neurological disease and controls are reported.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalEuropean Neurology
Issue number1
Publication statusPublished - 1997 Jan
Externally publishedYes


  • DNA polymorphism
  • Dopamine receptor subtype
  • Dopamine transporter
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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