Polymorphic ring-shaped molecular clusters made of shape-variable building blocks

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Self-assembling molecular building blocks able to dynamically change their shapes, is a concept that would offer a route to reconfigurable systems. Although simulation studies predict novel properties useful for applications in diverse fields, such kinds of building blocks, have not been implemented thus far with molecules. Here, we report shape-variable building blocks fabricated by DNA self-assembly. Blocks are movable enough to undergo shape transitions along geometrical ranges. Blocks connect to each other and assemble into polymorphic ring-shaped clusters via the stacking of DNA blunt-ends. Reconfiguration of the polymorphic clusters is achieved by the surface diffusion on mica substrate in response to a monovalent salt concentration. This work could inspire novel reconfigurable self-assembling systems for applications in molecular robotics.

Original languageEnglish
Pages (from-to)208-217
Number of pages10
Issue number1
Publication statusPublished - 2015 Feb 16


  • DNA nanostructure
  • DNA origami
  • DNA stacking
  • Reconfiguration
  • Substrate

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)


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