Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

Hiroshi Aoyama, Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba, Yuichi Hashimoto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalHeterocycles
Volume77
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1
Externally publishedYes

Keywords

  • Anti-BVDV Agent
  • Buchwald-Hartwig Amination
  • Palladium-Catalyzed
  • Quantitative Structure-Activity Relationship (QSAR)
  • γ-Carboline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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