Polymeric ethyl glyoxylate in an asymmetric aldol reaction catalyzed by diarylprolinol

Tatsuya Urushima, Yusuke Yasui, Hayato Ishikawa, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Diarylprolinol was found to be an effective organocatalyst of the direct, enantioselective aldol reaction of commercially available polymeric ethyl glyoxylate, affording γ-ethoxycarbonyl-β-hydroxy aldehydes, versatile synthetic intermediates, in good yield with excellent enantioselectivity.

Original languageEnglish
Pages (from-to)2966-2969
Number of pages4
JournalOrganic letters
Volume12
Issue number13
DOIs
Publication statusPublished - 2010 Jul 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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