Polymer-supported catalysts for efficient on-column preparation of 2-deoxy-2-[18F]fluoro-D-glucose

Katsuhiko Ohsaki, Yoshitake Endo, Shigeki Yamazaki, Masao Tomoi, Ren Iwata

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Several kinds of polymer-supported quaternary salts, such as dimethylaminopyridinium or tributylphosphonium salts, have been examined for the on-column preparation of [18F]FDG. Factors affecting [18F]fluoride trapping efficiency and [18F]fluorination yield have been optimized. [18F]Fluoride was practically, quantitatively trapped from flowing water and the subsequent 18F-substitution was carried out on-column with a radiochemical yield of over 70% (EOB). The improvement in the [18F]fluorination yield was achieved by introducing a spacer alkene chain between the supporting resin molecule and the catalytic site. A resin with higher cross-linkage and lower content of catalytic sites was shown to be useful for preventing column plugging.

    Original languageEnglish
    Pages (from-to)373-378
    Number of pages6
    JournalApplied Radiation and Isotopes
    Issue number4
    Publication statusPublished - 1998 Apr

    ASJC Scopus subject areas

    • Radiation


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