Poly(lactide-co-glycolide)/titania composite microsphere-sintered scaffolds for bone tissue engineering applications

Yingjun Wang, Xuetao Shi, Li Ren, Yongchang Yao, Feng Zhang, Dong An Wang

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    The objective of this study was to synthesize and characterize novel threedimensional porous scaffolds made of poly(lactic-co-glycolic acid) (PLGA)/nano-TiO2-particle composite microspheres for potential bone repair applications. The introduction of TiO2 component has been proven capable of largely enhancing mechanical properties of PLGA/ TiO 2 microsphere-sintered scaffold ("PLGA/TiO2- SMS"). In addition, composite nano-TiO2 additives are capable of inducing an increased arrest of adhesive proteins from the environment, which benefits cell attachment onto the scaffolds. Osteoblast proliferation and maturation were evaluated by MTT assay, alkaline phosphatase (ALP) activity, and bony calcification assay. The results indicate that osteoblasts cultured on the composite scaffolds with different TiO2 content (0, 0.1, and 0.3 g/1 g PLGA) display increased cell proliferation compared with pure PLGA scaffold. When cultured on composite scaffolds, osteoblasts also exhibit significantly enhanced ALP activity and higher calcium secretion, with respect to those on the pure PLGA scaffolds. Taken together, PLGA/TiO2-SMSs deserve attention utilizing for potential bone-repairing therapeutics.

    Original languageEnglish
    Pages (from-to)84-92
    Number of pages9
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    Volume93
    Issue number1
    DOIs
    Publication statusPublished - 2010 Apr 1

    Keywords

    • Bone repair
    • Microspheres
    • PLGA
    • Scaffold
    • TiO nanoparticles

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering

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