Abstract
Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.
Original language | English |
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Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | Cancer Letters |
Volume | 122 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1998 Jan 9 |
Keywords
- Gas chromatography nitrogen-phosphorus detection
- Leukemia
- Marker
- Polyamine profile
ASJC Scopus subject areas
- Oncology
- Cancer Research