Polyamine profiles in the urine of patients with leukemia

Seon Hwa Lee; Ja Won Suh; Bong Chul Chung; Soon Ok Kim

doi:10.1016/S0304-3835(97)00399-6

Polyamine profiles in the urine of patients with leukemia

Seon Hwa Lee, Ja Won Suh, Bong Chul Chung, Soon Ok Kim

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N¹-acSpd/N⁸-acSpd could be used as a diagnostic marker and the level of N¹,N¹²-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N¹,N¹²-diacetylspermine can be produced directly from spermine and N¹,N¹²-diacetylspermine is a major source of N¹-acetylspermidine.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Cancer Letters
Volume	122
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(97)00399-6
Publication status	Published - 1998 Jan 9

Keywords

Gas chromatography nitrogen-phosphorus detection
Leukemia
Marker
Polyamine profile

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Polyamine profiles in the urine of patients with leukemia",

abstract = "Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.",

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AU - Lee, Seon Hwa

AU - Suh, Ja Won

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N2 - Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.

AB - Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.

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