Poly-vinyl alcohol hydrogel vascular models for in vitro aneurysm simulations: The key to low friction surfaces

Makoto Ohta, Akira Handa, Hiroo Iwata, Daniel A. Rüfenacht, Sadami Tsutsumi

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

Purpose: To develop a vessel model with poly-vinyl alcohol hydrogel (PVA-H) with low surface friction for in vitro simulations of vascular pathologies. Materials and methods: Simulations of variable vascular pathologies were based on human vessel casts reproduced in wax. Constructions of vascular models were then obtained by lost wax techniques. As materials, liquid silicon or PVA in organic solvents were used. After solidification, the wax was drained by heating. Comparison of PVA-H with silicone models included evaluation of surface characteristics (friction coefficient), of visibility (transparence and compatibility with medical imaging techniques), and of stiffness (pulsatility of vascular lumen). Both model types were integrated in a circulation circuit allowing for flow simulations and testing with endovascular medical devices. Results and conclusion: Both model types were transparent and compatible with current medical imaging methods. PVA-H models exhibited much lower friction characteristics. PVA-H stiffness was closer to soft tissue when compared to silicone, allowing for pulsations during flow simulations.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalTechnology and Health Care
Volume12
Issue number3
Publication statusPublished - 2004 Sep 13
Externally publishedYes

Keywords

  • Aneurysm
  • Endovascular treatment
  • Friction
  • Phantom
  • Poly-vinyl alcohol hydrogel (PVA-H)

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Information Systems
  • Biomedical Engineering
  • Health Informatics

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