Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

Hajime Tei; Itsuko Nihonmatsu; Takakazu Yokokura; Ryu Ueda; Yumiko Sano; Takashi Okuda; Kanako Sato; Kanako Hirata; Shinobu C. Fujita; Daisuke Yamamoto

doi:10.1073/pnas.89.15.6856

Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

Hajime Tei, Itsuko Nihonmatsu, Takakazu Yokokura, Ryu Ueda, Yumiko Sano, Takashi Okuda, Kanako Sato, Kanako Hirata, Shinobu C. Fujita, Daisuke Yamamoto

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds, sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

Original language	English
Pages (from-to)	6856-6860
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	15
DOIs	https://doi.org/10.1073/pnas.89.15.6856
Publication status	Published - 1992
Externally published	Yes

Keywords

Compound eye
Neuronal fate determination
Transcription factor

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.89.15.6856

Cite this

Tei, H., Nihonmatsu, I., Yokokura, T., Ueda, R., Sano, Y., Okuda, T., Sato, K., Hirata, K., Fujita, S. C., & Yamamoto, D. (1992). Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. Proceedings of the National Academy of Sciences of the United States of America, 89(15), 6856-6860. https://doi.org/10.1073/pnas.89.15.6856

Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. / Tei, Hajime; Nihonmatsu, Itsuko; Yokokura, Takakazu et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 15, 1992, p. 6856-6860.

Research output: Contribution to journal › Article › peer-review

Tei, H, Nihonmatsu, I, Yokokura, T, Ueda, R, Sano, Y, Okuda, T, Sato, K, Hirata, K, Fujita, SC & Yamamoto, D 1992, 'Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor', Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 15, pp. 6856-6860. https://doi.org/10.1073/pnas.89.15.6856

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abstract = "Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds, sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means {"}dropping dead{"}) that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.",

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AU - Tei, Hajime

AU - Nihonmatsu, Itsuko

AU - Yokokura, Takakazu

AU - Ueda, Ryu

AU - Sano, Yumiko

AU - Okuda, Takashi

AU - Sato, Kanako

AU - Hirata, Kanako

AU - Fujita, Shinobu C.

AU - Yamamoto, Daisuke

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AB - Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds, sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

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KW - Neuronal fate determination

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Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

Abstract

Keywords

ASJC Scopus subject areas

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