Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

Hajime Tei, Itsuko Nihonmatsu, Takakazu Yokokura, Ryu Ueda, Yumiko Sano, Takashi Okuda, Kanako Sato, Kanako Hirata, Shinobu C. Fujita, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds, sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

    Original languageEnglish
    Pages (from-to)6856-6860
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume89
    Issue number15
    DOIs
    Publication statusPublished - 1992

    Keywords

    • Compound eye
    • Neuronal fate determination
    • Transcription factor

    ASJC Scopus subject areas

    • General

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