Point-of-care nucleic acid detection using nanotechnology

Mark R. Hartman, Roanna C.H. Ruiz, Shogo Hamada, Chuanying Xu, Kenneth G. Yancey, Yan Yu, Wei Han, Dan Luo

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Recent developments in nanotechnology have led to significant advancements in point-of-care (POC) nucleic acid detection. The ability to sense DNA and RNA in a portable format leads to important applications for a range of settings, from on-site detection in the field to bedside diagnostics, in both developing and developed countries. We review recent innovations in three key process components for nucleic acid detection: sample preparation, target amplification, and read-out modalities. We discuss how the advancements realized by nanotechnology are making POC nucleic acid detection increasingly applicable for decentralized and accessible testing, in particular for the developing world.

Original languageEnglish
Pages (from-to)10141-10154
Number of pages14
JournalNanoscale
Volume5
Issue number21
DOIs
Publication statusPublished - 2013 Nov 7
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)

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