Podocalyxin expression in malignant astrocytic tumors

Norihito Hayatsu, Mika Kato Kaneko, Kazuhiko Mishima, Ryo Nishikawa, Masao Matsutani, Janet E. Price, Yukinari Kato

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Podocalyxin is an anti-adhesive mucin-like transmembrane sialoglycoprotein that has been implicated in the development of aggressive forms of cancer. Podocalyxin is also known as keratan sulfate (KS) proteoglycan. Recently, we revealed that highly sulfated KS or another mucin-like transmembrane sialoglycoprotein podoplanin/aggrus is upregulated in malignant astrocytic tumors. The aim of this study is to examine the relationship between podocalyxin expression and malignant progression of astrocytic tumors. In this study, 51 astrocytic tumors were investigated for podocalyxin expression using immunohistochemistry, Western blot analysis, and quantitative real-time PCR. Immunohistochemistry detected podocalyxin on the surface of tumor cells in six of 14 anaplastic astrocytomas (42.9%) and in 17 of 31 glioblastomas (54.8%), especially around proliferating endothelial cells. In diffuse astrocytoma, podocalyxin expression was observed only in vascular endothelial cells. Podocalyxin might be associated with the malignant progression of astrocytic tumors, and be a useful prognostic marker for astrocytic tumors.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalBiochemical and biophysical research communications
Volume374
Issue number2
DOIs
Publication statusPublished - 2008 Sep 19
Externally publishedYes

Keywords

  • Astrocytic tumor
  • Glioblastoma
  • Keratan sulfate
  • Podocalyxin
  • Proteoglycan

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Podocalyxin expression in malignant astrocytic tumors'. Together they form a unique fingerprint.

Cite this