Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537

Rei Miyano, Hirotaka Matsuo, Kenichi Nonaka, Takayuki Mokudai, Yoshimi Niwano, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New natural products, designated pochoniolides A and B, were isolated from the cultured broth of fungal strain FKI-7537 using a physicochemical screening methodology. Strain FKI-7537 was isolated from a soil sample collected at Niijima, Tokyo, Japan and identified as Pochonia chlamydosporia var. spinulospora by morphological characteristics and DNA sequence analysis. The chemical structures of pochoniolides A and B were elucidated by NMR and mass spectra and found to be new compounds consisting of a muconolactone moiety connected with a chromone unit. Pochoniolides A and B were identified as racemate mixtures using data on optical rotation and circular dichroism spectra. Furthermore, enantiomers of pochoniolide B, pochoniolides B1 and B2, were separated using a chiral HPLC column. Pochoniolides A and B showed hydroxyl radical-scavenging and singlet oxygen-quenching activities.

Original languageEnglish
Pages (from-to)661-666
Number of pages6
JournalJournal of Bioscience and Bioengineering
Volume126
Issue number5
DOIs
Publication statusPublished - 2018 Nov

Keywords

  • Antioxidant
  • Muconolactone
  • Physicochemical screening
  • Pochonia chlamydosporia var. spinulospora
  • Pochoniolides

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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