TY - JOUR
T1 - PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells
AU - Yamada, Shinji
AU - Itai, Shunsuke
AU - Kaneko, Mika K.
AU - Kato, Yukinari
PY - 2018/2
Y1 - 2018/2
N2 - Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.
AB - Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.
KW - dog podoplanin
KW - immunohistochemistry
KW - monoclonal antibody
UR - http://www.scopus.com/inward/record.url?scp=85042623349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042623349&partnerID=8YFLogxK
U2 - 10.1089/mab.2017.0053
DO - 10.1089/mab.2017.0053
M3 - Article
C2 - 29256716
AN - SCOPUS:85042623349
VL - 37
SP - 63
EP - 66
JO - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
JF - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
SN - 2167-9436
IS - 1
ER -