PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells

Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Yukinari Kato

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalMonoclonal antibodies in immunodiagnosis and immunotherapy
Volume37
Issue number1
DOIs
Publication statusPublished - 2018 Feb

Keywords

  • dog podoplanin
  • immunohistochemistry
  • monoclonal antibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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