TY - JOUR
T1 - PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells
AU - Yamada, Shinji
AU - Itai, Shunsuke
AU - Kaneko, Mika K.
AU - Kato, Yukinari
N1 - Funding Information:
Y.K. received research funding from Ono Pharmaceutical Co., Ltd. All other authors have no conflicts of interest.
Funding Information:
This work was supported in part by the Basic Science and Platform Technology Program for Innovative Biological Medicine from Japan Agency for Medical Research and Development, AMED (Y.K.) and by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from AMED (Y.K.).
Publisher Copyright:
© Copyright 2018, Mary Ann Liebert, Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.
AB - Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.
KW - dog podoplanin
KW - immunohistochemistry
KW - monoclonal antibody
UR - http://www.scopus.com/inward/record.url?scp=85042623349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042623349&partnerID=8YFLogxK
U2 - 10.1089/mab.2017.0053
DO - 10.1089/mab.2017.0053
M3 - Article
C2 - 29256716
AN - SCOPUS:85042623349
VL - 37
SP - 63
EP - 66
JO - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
JF - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
SN - 2167-9436
IS - 1
ER -