Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

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Abstract

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalCase Reports in Dermatology
Volume8
Issue number1
DOIs
Publication statusPublished - 2016

Keywords

  • Immunomodulation
  • Periostin
  • Plexiform fibrohistiocytic tumor
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Dermatology

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