Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells

Yasufumi Sato, Mayumi Abe, Ryosaburo Takaki

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five μg/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 μg/ml of PF-4, where the binding of bFGF to the receptor was completely blocked.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalBiochemical and biophysical research communications
Volume172
Issue number2
DOIs
Publication statusPublished - 1990 Oct 30
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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