Platelet-activating-factor-mediated pathogenesis in Lyme disease

Emiko Isogai, Koichi Kimura, Nobuhiro Fujii, Takeshi Nishikawa, Norihisa Ishii, Daniele Postic, Guy Baranton, Hiroshi Isogai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


This study describes a role of platelet-activating factor (PAF) as a potential inducer of inflammation in infection with Borrelia burgdorferi. Two approaches were taken. The first involved the use of a PAF antagonist to show the lack of an inflammatory response in skin lesions. The second was to show that the PAF antagonist reduced platelet aggregation when the spirochetes were incubated with polymorphonuclear leukocytes.

Original languageEnglish
Pages (from-to)1026-1029
Number of pages4
JournalInfection and immunity
Issue number3
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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