Plasma soluble interleukin-2 receptor levels during and after upper abdominal surgery

M. Kato, S. Kurosawa, H. Matsuoka, M. Murakami, R. Imai, M. Takahashi

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    1 Citation (Scopus)


    Soluble interleukin-2 (IL-2) receptor (sIL-2R) is reported to be up-regulated in inflammatory disorders. Although sIL-2R may modulate perioperative inflammatory responses, it remains unclear whether upper abdominal surgery affects plasma sIL-2R levels. We evaluated the influence of major abdominal surgery on plasma sIL-2R levels. Ten patients scheduled for upper abdominal surgery received anaesthesia with isoflurane, nitrous oxide, and epidural block. Plasma sIL-2R and IL-6 levels were determined at pre-anaesthesia, 0, 2, and 4 hours during surgery, and on postoperative days 1 (POD1) and 3 (POD3). The plasma levels of sIL-2R decreased significantly and achieved their minimum value at 4 hours (677.0±125.3 pg/ml, P<0.01 compared to pre-anaesthesia value; 924.5±178.8 pg/ml, 95% confidence interval=122.2-550.4). The plasma sIL-2R levels increased on POD1 (1336.5±174.0 pg/ml) and POD3 (1629.0±262.8 pg/ml), and reached a level significantly higher than the baseline (P<0.05 and P<0.001, 95% confidence interval=93.4-730.6 and 402.8-1006.2, respectively). The plasma sIL-2R levels on POD3 significantly correlated with the peak IL-6 levels (r=0.67, P<0.05). The plasma sIL-2R levels on POD3 correlated with the amount of intraoperative bleeding (r=0.66, P<0.05). In conclusion, we found that major abdominal surgery induces characteristic changes in plasma soluble IL-2 receptor levels.

    Original languageEnglish
    Pages (from-to)650-653
    Number of pages4
    JournalAnaesthesia and Intensive Care
    Issue number6
    Publication statusPublished - 2000


    • Cytokine: soluble interleukin-2 receptor
    • Interleukin-6; stress: surgery

    ASJC Scopus subject areas

    • Critical Care and Intensive Care Medicine
    • Anesthesiology and Pain Medicine


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