Plasma plasminogen activator inhibitor-1, tissue plasminogen activator and serum lipoprotein(a) after reperfusion therapy in acute myocardial infarction: Comparison between sequential and direct percutaneous transluminal coronary angioplasty

Masahide Hara, Kenichiro Ito, Tomoko Nawata, Yoshihiro Tsunematsu, Nobuo Shimoyama, Toshihiro Maeda, Yasufumi Sato, Tetsunori Saikawa, Tosh He Sakata

Research output: Contribution to journalArticlepeer-review

Abstract

To determine which reperfusion therapy for acute myocardial infarction (AMI) is advantageous to avoid subsequent thrombotic coronary occlusion, 8 patients with AMI were studied. Four of them (group S) underwent sequential PTCA following unsuccessful intracoronary thrombolysis and the others (group D) direct PTCA. Serial changes in plasma plasminogen activator inhibitor-1 (PAI-1), plasma tissue plasminogen activator (t-PA) antigen and serum lipoprotein(a) levels were compared between the two groups. In group S, plasma PAI-1 levels showed no significant serial change after PTCA. However, in group D, plasma PAI-1 levels increased significantly 4-24 h after PTCA. We suggest that more attention should be focused on the prevention of thrombotic coronary closure as well as mechanical abrupt occlusion after direct PTCA.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalCardiology (Switzerland)
Volume86
Issue number5
DOIs
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Acute myocardial infarction
  • Lipoprotein(a)
  • Percutaneous transluminal coronary angioplasty
  • Plasminogen activator inhibitor-1
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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