Plasma osteopontin levels is associated with biochemical markers of kidney injury in patients with leptospirosis

Horuro (None), Firmanto Hanan, Toshiro Niki, Gaowa Bai, Yugo Ashino, Shinichi Egawa, Elizabeth Freda O. Telan, Toshio Hattori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were measured to understand the pathological and diagnostic roles of OPN and Gal-9 in leptospirosis. Plasma levels of full-length (FL)-OPN (pFL-OPN) (p < 0.0001), pFL-Gal-9(p < 0.0001) and thrombin-cleaved OPN (p < 0.01) were significantly higher in patients with leptospirosis than in healthy controls (n = 30), as were levels of several indicators of renal toxicity: serum cystatin C (p < 0.0001), urine N-acetyl-β-glucosaminidase (NAG)/creatinine (p < 0.05), and urine clusterin/creatinine (p < 0.05). pFL-Gal-9 levels were negatively correlated with pFL-OPN levels (r = -0.24, p < 0.05). pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels. In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (p < 0.0001) and pFL-OPN (p < 0.001) were observed. Our results demonstrate that pFL-OPN reflect kidney injury among patients with leptospirosis.

Original languageEnglish
Article number439
Issue number7
Publication statusPublished - 2020 Jul


  • Biomarker
  • Clusterin
  • Creatinine
  • Cystatin C
  • Galectin-9
  • Leptospirosis
  • Osteopontin

ASJC Scopus subject areas

  • Clinical Biochemistry


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