Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome

Tsuguo Nishijima, Shigeru Sakurai, Zenei Arihara, Kazuhiro Takahashi

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Orexin-A (hypocretin-1), a neuropeptide produced in hypothalamus, stimulates arousal. We studied plasma concentrations of orexin-A-like immunoreactivity (orexin-A-LI) in 156 patients with sleep apnea hypopnea syndrome (SAHS) and 22 control subjects. Plasma orexin-A-LI levels were significantly decreased in 156 patients with SAHS (4.4±0.15pmol/l, mean±S.E.) as compared with controls (5.3±0.45pmol/l). The levels were decreased in parallel with the severity of sleep-related respiratory disturbance and magnitude of sleep fragmentation. These findings raise the possibility that a low plasma level of orexin-A-LI may be a marker to show the severity of the disease in patients with SAHS.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalPeptides
Volume24
Issue number3
DOIs
Publication statusPublished - 2003 Mar 1

Keywords

  • Apnea
  • Hypocretin
  • Orexin
  • Plasma
  • Sleep

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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