Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity

Naoko Watanabe, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Yukio Kume, Tomoaki Tomiya, Kazuaki Tejima, Takako Nishikawa, Masahiro Arai, Mikio Yanase, Junken Aoki, Hiroyuki Arai, Masao Omata, Kenji Fujiwara, Yutaka Yatomi

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) is a lipid mediator with multiple biological actions. We have reported that LPA stimulates hepatic stellate cell proliferation and inhibits DNA synthesis in hepatocytes, suggesting that LPA might play some role in the liver. We have found that plasma LPA level and serum autotaxin (ATX) activity were increased in patients with chronic hepatitis C. However, the clinical significance of LPA and its synthetic enzyme, autotaxin (ATX), is still unclear. To determine whether the increase of plasma LPA level and serum ATX activity might be found generally in liver injury, we examined the possible modulation of them in the blood in rats with various liver injuries. Plasma LPA level and serum ATX activity were increased in carbon tetrachloride-induced liver fibrosis correlatively with fibrosis grade, in dimethylnitrosamine-induced acute liver injury correlatively with serum alanine aminotransferase level or in 70% hepatectomy as early as 3 h after the operation. Plasma LPA level was correlated with serum ATX activity in rats with chronic and acute liver injury. ATX mRNA in the liver was not altered in carbon tetrachloride-induced liver fibrosis. Plasma LPA level and serum ATX activity are increased in various liver injuries in relation to their severity. Whether increased ATX and LPA in the blood in liver injury is simply a result or also a cause of the injury should be further clarified.

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalLife Sciences
Volume81
Issue number12
DOIs
Publication statusPublished - 2007 Sep 1
Externally publishedYes

Keywords

  • Autotoxin
  • Carbon tetrachloride
  • Dimethylnitrosamine
  • Hepatectomy
  • Lysophosphatidic acid
  • Lysophospholipase D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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