Plasma endothelin-1 level in Japanese normal tension glaucoma patients

Shiho Kunimatsu, Chihiro Mayama, Atsuo Tomidokoro, Makoto Araie

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Purpose: To compare the plasma concentration of endothelin-1 (ET-1) among patients <60 years of age with normal-tension glaucoma (NTG), primary open-angle glaucoma (POAG), and in age-matched normal participants. Methods: Plasma concentration of ET-1 was determined in 30 NTG 18 POAG patients, and 19 age-matched normal participants using an enzyme immunoassay. Results: The ET-1 level was 1.49 ± 0.51 pg/ml in the NTG patients (49.4 ± 8.8 years), 1.58 ± 0.64 pg/ml in the POAG patients (44.7 ± 10.7 years), and 1.33 ± 0.50 pg/ml in the normal participants (49.9 ± 5.6 years). The ET-1 levels were not significantly different among the three groups, and no significant correlation with the extent of visual field damage, intraocular pressure (IOP), refraction, or age was seen in the glaucoma patients. Conclusions: The plasma ET-1 level showed no difference among NTG patients, POAG patients, and normal participants <60 years of age in the Japanese population.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalCurrent Eye Research
Volume31
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

Keywords

  • ET-1
  • Endothelin
  • Glaucoma
  • NTG
  • Plasma level

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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