Plasma Concentrations of Atrial Natriuretic Peptide in Various Diseases

Mitsuru Nozuki, Toraichi Mouri, Keiichi Itoi, Kazuhiro Takahashi, Kazuhito Totsune, Takao Saito, Kaoru Yoshinaga

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26 Citations (Scopus)


Using a radioimmunoassay for atrial natriuretic peptide (ANP) we studied plasma concentrations of immunoreactive ANP in order to investigate the pathophysiological role of ANP in patients with various diseases. Plasma ANP levels were elevated in patients with congestive heart failure (394±260 pg/ml, n = 8) and chronic renal failure (219±86 pg/ml, n = 11). In patients undergoing hemodialysis plasma ANP levels were markedly high and decreased after hemodialysis from 433 ±166 pg/ml to 204±92 pg/ml (n = 11). ANP was removed from blood to dialysate (21 ±13 pg/ ml of dialysate, rt = 6, dialysate flow:500ml/min). Plasma ANP level was conversely correlated with creatinine clearance (r= —0.812, p <0.001) in patients with renal diseases (n = 29). In patients with atrial fibrillation, pace maker implantation, lung disease, chronic glomerulonephritis, nephrotic syndrome, essential hypertension, liver disease and cerebrovascular disease, plasma ANP levels were not significantly different from those in normal subjects (70± 32 pg/ml, n = 28). These results suggest that ANP may be a circulating hormone playing pathophysiological roles in congestive heart failure and chronic renal failure.

Original languageEnglish
Pages (from-to)439-447
Number of pages9
Journalthe tohoku journal of experimental medicine
Issue number4
Publication statusPublished - 1986


  • plasma atrial natriuretic peptide
  • radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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