TY - JOUR
T1 - Plasma Concentrations of Atrial Natriuretic Peptide in Various Diseases
AU - Nozuki, Mitsuru
AU - Mouri, Toraichi
AU - Itoi, Keiichi
AU - Takahashi, Kazuhiro
AU - Totsune, Kazuhito
AU - Saito, Takao
AU - Yoshinaga, Kaoru
PY - 1986
Y1 - 1986
N2 - Using a radioimmunoassay for atrial natriuretic peptide (ANP) we studied plasma concentrations of immunoreactive ANP in order to investigate the pathophysiological role of ANP in patients with various diseases. Plasma ANP levels were elevated in patients with congestive heart failure (394±260 pg/ml, n = 8) and chronic renal failure (219±86 pg/ml, n = 11). In patients undergoing hemodialysis plasma ANP levels were markedly high and decreased after hemodialysis from 433 ±166 pg/ml to 204±92 pg/ml (n = 11). ANP was removed from blood to dialysate (21 ±13 pg/ ml of dialysate, rt = 6, dialysate flow:500ml/min). Plasma ANP level was conversely correlated with creatinine clearance (r= —0.812, p <0.001) in patients with renal diseases (n = 29). In patients with atrial fibrillation, pace maker implantation, lung disease, chronic glomerulonephritis, nephrotic syndrome, essential hypertension, liver disease and cerebrovascular disease, plasma ANP levels were not significantly different from those in normal subjects (70± 32 pg/ml, n = 28). These results suggest that ANP may be a circulating hormone playing pathophysiological roles in congestive heart failure and chronic renal failure.
AB - Using a radioimmunoassay for atrial natriuretic peptide (ANP) we studied plasma concentrations of immunoreactive ANP in order to investigate the pathophysiological role of ANP in patients with various diseases. Plasma ANP levels were elevated in patients with congestive heart failure (394±260 pg/ml, n = 8) and chronic renal failure (219±86 pg/ml, n = 11). In patients undergoing hemodialysis plasma ANP levels were markedly high and decreased after hemodialysis from 433 ±166 pg/ml to 204±92 pg/ml (n = 11). ANP was removed from blood to dialysate (21 ±13 pg/ ml of dialysate, rt = 6, dialysate flow:500ml/min). Plasma ANP level was conversely correlated with creatinine clearance (r= —0.812, p <0.001) in patients with renal diseases (n = 29). In patients with atrial fibrillation, pace maker implantation, lung disease, chronic glomerulonephritis, nephrotic syndrome, essential hypertension, liver disease and cerebrovascular disease, plasma ANP levels were not significantly different from those in normal subjects (70± 32 pg/ml, n = 28). These results suggest that ANP may be a circulating hormone playing pathophysiological roles in congestive heart failure and chronic renal failure.
KW - plasma atrial natriuretic peptide
KW - radioimmunoassay
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U2 - 10.1620/tjem.148.439
DO - 10.1620/tjem.148.439
M3 - Article
C2 - 2943055
AN - SCOPUS:0022470964
VL - 148
SP - 439
EP - 447
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 4
ER -