Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy

Masahiro Abe, Hisayuki Yokoyama, Yasuo Tohmiya, Yoko Okitsu, Hiroto Ohguchi, Katsura Kohata, Joji Yamamoto, Yasushi Onishi, Kenichi Ishizawa, Junichi Kameoka, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.

Original languageEnglish
Pages (from-to)1833-1835
Number of pages3
JournalInternal Medicine
Volume48
Issue number20
DOIs
Publication statusPublished - 2009

Keywords

  • Low-dose thalidomide
  • Plasma cell leukemia
  • Syngeneic stem cell transplantation

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy'. Together they form a unique fingerprint.

Cite this