Plant defense systems against cucumber mosaic virus: lessons learned from CMV–Arabidopsis interactions

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)

    Abstract

    To protect against infection, plants have evolved multi-layered defense systems such as RNA silencing, salicylic acid (SA)-mediated resistance, resistance (R) protein-conferred resistance and defense priming. Antiviral defense systems seem to act in a coordinated manner in response to viral infection, but the underlying mechanisms are unknown except in a limited number of specific virus–plant combinations. Cucumber mosaic virus (CMV) infection of Arabidopsis thaliana is a well-known sophisticated pathosystem often used to investigate antiviral defense reactions. On the basis of extensive studies on the interaction between CMV and A. thaliana, RNA silencing plays a key role in suppressing CMV infection in the host plant. However, several strains of CMV are able to overcome the RNA silencing system by producing an RNA silencing suppressor protein. If the virulent CMV strain is indeed able to overcome basal antiviral RNA silencing, host plants carrying the R gene exhibit a resistance response, generally accompanied by necrotic local lesions at the primary infection sites. RCY1, which encodes an NB-LRR class R protein, was isolated from A. thaliana and identified as the first R gene conferring resistance to CMV. SA-dependent and -independent signaling pathways also seem to be associated with CMV resistance, while in A. thaliana, resistance induced by a plant activator treatment is thought to activate defense priming against a broad range of pathogens. In this review, we summarize current knowledge on the multiple defense systems of A. thaliana against CMV infection.

    Original languageEnglish
    Pages (from-to)174-181
    Number of pages8
    JournalJournal of General Plant Pathology
    Volume85
    Issue number3
    DOIs
    Publication statusPublished - 2019 May 15

    Keywords

    • Defense priming
    • R gene
    • RNA silencing
    • Salicylic acid

    ASJC Scopus subject areas

    • Agronomy and Crop Science
    • Plant Science

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