TY - JOUR
T1 - Plant anticancer agents XXXIX
T2 - Triterpenes from Iris missouriensis (Iridaceae)1
AU - Wong, Sui‐Ming ‐M
AU - Oshima, Yoshiteru
AU - Pezzuto, John M.
AU - Fong, Harry H.S.
AU - Farnsworth, Norman R.
N1 - Funding Information:
The authors are grateful to Ms. D. Guilty for aid in the reparation of this manuscript, and would like to thank Dr. F. J. darner for a sample of iso-irido ermanal and Dr. I. Kitagawa for a sample of zeorin. In vivo test iata are the results of screenin performed under the auspices of the Developmental Therapeutics trogram, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD. This work was supported, in art, by grant CA 33047 from the NCI. J.M.P. is the recipient ofa Research Career Development Award from the NCI, 1984-1989.
PY - 1986/3
Y1 - 1986/3
N2 - Employing the roots of Iris missouriensis, two known triterpenes, iso‐iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P‐388 cells (ED50 = 0.1 and 1.1 μg/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 μg/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6α‐hydroxy‐A'‐neogermmacer‐22(29)‐en‐30‐oic acid (missourin).
AB - Employing the roots of Iris missouriensis, two known triterpenes, iso‐iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P‐388 cells (ED50 = 0.1 and 1.1 μg/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 μg/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6α‐hydroxy‐A'‐neogermmacer‐22(29)‐en‐30‐oic acid (missourin).
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U2 - 10.1002/jps.2600750324
DO - 10.1002/jps.2600750324
M3 - Article
C2 - 3701620
AN - SCOPUS:0022640127
VL - 75
SP - 317
EP - 320
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 3
ER -