Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae)1

Sui‐Ming ‐M Wong, Yoshiteru Oshima, John M. Pezzuto, Harry H.S. Fong, Norman R. Farnsworth

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Employing the roots of Iris missouriensis, two known triterpenes, iso‐iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P‐388 cells (ED50 = 0.1 and 1.1 μg/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 μg/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6α‐hydroxy‐A'‐neogermmacer‐22(29)‐en‐30‐oic acid (missourin).

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume75
Issue number3
DOIs
Publication statusPublished - 1986 Mar

ASJC Scopus subject areas

  • Pharmaceutical Science

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