Placental autotaxin expression is diminished in women with pre-eclampsia

Mayuko Ichikawa, Takeshi Nagamatsu, Danny J. Schust, Yuki Kawai-Iwasawa, Kei Kawana, Takahiro Yamashita, Yutaka Osuga, Junken Aoki, Yutaka Yatomi, Tomoyuki Fujii

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Aim Lysophosphatidic acid (LPA) is a member of a new class of lipid mediators and exerts varied physiological and pathological functions. The secreted protein, autotaxin (ATX), is a key enzymatic determinant of local LPA production. The primary aim of this study was to investigate the potential involvement of the placental ATX-LPA system in pre-eclampsia (PE). Material and Methods We compared human placental ATX mRNA expression in pregnancies complicated by severe PE with that in healthy placentas using real-time polymerase chain reaction. We further assessed whether these expression levels were associated with disease-onset patterns. Results Placental transcription of ATX increased progressively during normal pregnancy. In the analysis for pre-eclamptic placentas, the placental ATX expression in the early-onset group, but not in late-onset group, was significantly lower compared to normal controls. Multiple regression analysis revealed that occurrence of early-onset PE, but not late-onset PE, was a variable that was significantly associated with the placental ATX expression level. Conclusion These findings support our previous work showing reduced ATX antigen levels in the peripheral blood of pre-eclamptic women. A disturbance in placental ATX production may be linked to poor placental development and systemic maternal symptoms in early-onset PE.

Original languageEnglish
Pages (from-to)1406-1411
Number of pages6
JournalJournal of Obstetrics and Gynaecology Research
Volume41
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • autotaxin
  • lysophosphatidic acid
  • placenta
  • pre-eclampsia
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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