PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin

A. Terakawa; K. Ishii; H. Yamazaki; S. Matsuyama; Y. Kikuchi; Y. Ito; A. Tagawa; S. Yasunaga; T. Kawamura; Y. Takahashi; Y. Hatori; N. Hamada; K. Fujiki; N. Ito; S. Wada; Y. Funaki; K. Sera

doi:10.1002/xrs.1338

PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin

A. Terakawa, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Ito, A. Tagawa, S. Yasunaga, T. Kawamura, Y. Takahashi, Y. Hatori, N. Hamada, K. Fujiki, N. Ito, S. Wada, Y. Funaki, K. Sera

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Abstract

Platinum concentration in a murine solid tumor treated with proton therapy combined with the platinum-based chemotherapeutic agent cisplatin [cis-diamminedichloro-platinum(II) (CDDP)] was investigated with conventional and submilli-PIXE (particle-induced X-ray emission) analyses. An enhanced therapeutic effect on tumor growth was observed in NFSa fibrosarcoma tumors in mice when proton therapy with a single dose of 30 Gy and CDDP treatment (10 mg/kg) were combined. The conventional PIXE analysis based on an internal standard method showed that the platinum concentration was 2.6 ± 0.3 μg/g for the tumor samples excised from the mice 6 h after the CDDP administration. The submilli-PIXE analysis of the tumor sections showed that spatial distribution of CDDP may be more or less uniform in the tumor.

Original language	English
Pages (from-to)	198-201
Number of pages	4
Journal	X-Ray Spectrometry
Volume	40
Issue number	3
DOIs	https://doi.org/10.1002/xrs.1338
Publication status	Published - 2011 May

ASJC Scopus subject areas

Spectroscopy

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Terakawa, A., Ishii, K., Yamazaki, H., Matsuyama, S., Kikuchi, Y., Ito, Y., Tagawa, A., Yasunaga, S., Kawamura, T., Takahashi, Y., Hatori, Y., Hamada, N., Fujiki, K., Ito, N., Wada, S., Funaki, Y., & Sera, K. (2011). PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin. X-Ray Spectrometry, 40(3), 198-201. https://doi.org/10.1002/xrs.1338

Terakawa, A, Ishii, K, Yamazaki, H, Matsuyama, S , Kikuchi, Y, Ito, Y, Tagawa, A, Yasunaga, S, Kawamura, T, Takahashi, Y, Hatori, Y, Hamada, N, Fujiki, K, Ito, N, Wada, S, Funaki, Y & Sera, K 2011, 'PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin', X-Ray Spectrometry, vol. 40, no. 3, pp. 198-201. https://doi.org/10.1002/xrs.1338

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title = "PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin",

abstract = "Platinum concentration in a murine solid tumor treated with proton therapy combined with the platinum-based chemotherapeutic agent cisplatin [cis-diamminedichloro-platinum(II) (CDDP)] was investigated with conventional and submilli-PIXE (particle-induced X-ray emission) analyses. An enhanced therapeutic effect on tumor growth was observed in NFSa fibrosarcoma tumors in mice when proton therapy with a single dose of 30 Gy and CDDP treatment (10 mg/kg) were combined. The conventional PIXE analysis based on an internal standard method showed that the platinum concentration was 2.6 ± 0.3 μg/g for the tumor samples excised from the mice 6 h after the CDDP administration. The submilli-PIXE analysis of the tumor sections showed that spatial distribution of CDDP may be more or less uniform in the tumor.",

author = "A. Terakawa and K. Ishii and H. Yamazaki and S. Matsuyama and Y. Kikuchi and Y. Ito and A. Tagawa and S. Yasunaga and T. Kawamura and Y. Takahashi and Y. Hatori and N. Hamada and K. Fujiki and N. Ito and S. Wada and Y. Funaki and K. Sera",

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AU - Terakawa, A.

AU - Ishii, K.

AU - Yamazaki, H.

AU - Matsuyama, S.

AU - Kikuchi, Y.

AU - Ito, Y.

AU - Tagawa, A.

AU - Yasunaga, S.

AU - Kawamura, T.

AU - Takahashi, Y.

AU - Hatori, Y.

AU - Hamada, N.

AU - Fujiki, K.

AU - Ito, N.

AU - Wada, S.

AU - Funaki, Y.

AU - Sera, K.

PY - 2011/5

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AB - Platinum concentration in a murine solid tumor treated with proton therapy combined with the platinum-based chemotherapeutic agent cisplatin [cis-diamminedichloro-platinum(II) (CDDP)] was investigated with conventional and submilli-PIXE (particle-induced X-ray emission) analyses. An enhanced therapeutic effect on tumor growth was observed in NFSa fibrosarcoma tumors in mice when proton therapy with a single dose of 30 Gy and CDDP treatment (10 mg/kg) were combined. The conventional PIXE analysis based on an internal standard method showed that the platinum concentration was 2.6 ± 0.3 μg/g for the tumor samples excised from the mice 6 h after the CDDP administration. The submilli-PIXE analysis of the tumor sections showed that spatial distribution of CDDP may be more or less uniform in the tumor.

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PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin

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