PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin

A. Terakawa, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Ito, A. Tagawa, S. Yasunaga, T. Kawamura, Y. Takahashi, Y. Hatori, N. Hamada, K. Fujiki, N. Ito, S. Wada, Y. Funaki, K. Sera

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Platinum concentration in a murine solid tumor treated with proton therapy combined with the platinum-based chemotherapeutic agent cisplatin [cis-diamminedichloro-platinum(II) (CDDP)] was investigated with conventional and submilli-PIXE (particle-induced X-ray emission) analyses. An enhanced therapeutic effect on tumor growth was observed in NFSa fibrosarcoma tumors in mice when proton therapy with a single dose of 30 Gy and CDDP treatment (10 mg/kg) were combined. The conventional PIXE analysis based on an internal standard method showed that the platinum concentration was 2.6 ± 0.3 μg/g for the tumor samples excised from the mice 6 h after the CDDP administration. The submilli-PIXE analysis of the tumor sections showed that spatial distribution of CDDP may be more or less uniform in the tumor.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalX-Ray Spectrometry
Volume40
Issue number3
DOIs
Publication statusPublished - 2011 May

ASJC Scopus subject areas

  • Spectroscopy

Fingerprint Dive into the research topics of 'PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin'. Together they form a unique fingerprint.

Cite this