Pituitary regulation of sex-specific forms of cytochrome P-450 in liver microsomes of rats

Tetsuya Kamataki, Miki Shimada, Kaori Maeda, Ryuichi Kato

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    Effects of hypophysectomy and treatment with testosterone or estradiol on the sex-specific forms of cytochrome P-450, P-450-male and P-450-female, were examined. The amounts of P-450-male as well as drug oxidation activities were decreased by hypophysectomy of male rats. In female rats, drug oxidation activities were increased by hypophysectomy, which was associated with the disappearance of P-450-female and the appearance of P-450-male. Treatment of hypophysectomized female rats with testosterone or estrodiol effected minor changes in the amounts of P-450-male.

    Original languageEnglish
    Pages (from-to)1247-1253
    Number of pages7
    JournalBiochemical and biophysical research communications
    Volume130
    Issue number3
    DOIs
    Publication statusPublished - 1985 Aug 15

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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