Pituitary regulation of sex-specific forms of cytochrome P-450 in liver microsomes of rats

Tetsuya Kamataki, Miki Shimada, Kaori Maeda, Ryuichi Kato

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

Effects of hypophysectomy and treatment with testosterone or estradiol on the sex-specific forms of cytochrome P-450, P-450-male and P-450-female, were examined. The amounts of P-450-male as well as drug oxidation activities were decreased by hypophysectomy of male rats. In female rats, drug oxidation activities were increased by hypophysectomy, which was associated with the disappearance of P-450-female and the appearance of P-450-male. Treatment of hypophysectomized female rats with testosterone or estrodiol effected minor changes in the amounts of P-450-male.

Original languageEnglish
Pages (from-to)1247-1253
Number of pages7
JournalBiochemical and biophysical research communications
Volume130
Issue number3
DOIs
Publication statusPublished - 1985 Aug 15
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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