Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A2 receptor antagonist

Masaya Iwashita, Nobuaki Oka, Satoko Ohkubo, Masaki Saito, Norimichi Nakahata

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Piper longum L. has been used as a crude drug for the treatment of the disorder of peripherally poor blood circulation in Asia. In the present study, we examined the effect of piperlongumine, a constituent of P. longum L., on rabbit platelet aggregation. Piperlongumine concentration-dependently inhibited platelet aggregation induced by thromboxane A2 receptor agonist U46619, but it only slightly inhibited thrombin-induced one. Piperlongumine also inhibited U46619-induced phosphatidylinositol hydrolysis and the binding of [3H]SQ29548 to thromboxane A2 receptor with a similar concentration-dependency to the aggregation. It is assumed that piperlongumine inhibits platelet aggregation as a thromboxane A2 receptor antagonist.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalEuropean Journal of Pharmacology
Volume570
Issue number1-3
DOIs
Publication statusPublished - 2007 Sep 10

Keywords

  • Piperlongumine
  • Platelet aggregation
  • Thromboxane A receptor

ASJC Scopus subject areas

  • Pharmacology

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