Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

Kentaro Ohuchi; Taku Fujimura; Yumi Kambayashi; Hisayuki Tono; Eika Ohtake; Akira Hashimoto; Setsuya Aiba

doi:10.1159/000490237

Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

Kentaro Ohuchi, Taku Fujimura, Yumi Kambayashi, Hisayuki Tono, Eika Ohtake, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

Abstract

Pigmented epithelioid melanocytoma (PEM), also known as an animal-Type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-Associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.

Original language	English
Pages (from-to)	378-382
Number of pages	5
Journal	Case Reports in Oncology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1159/000490237
Publication status	Published - 2018 May 1

Keywords

CD163
PD-L1
Pigmented epithelioid melanocytoma
Prognosis
Tumor-Associated macrophages

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000490237

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title = "Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose",

abstract = "Pigmented epithelioid melanocytoma (PEM), also known as an animal-Type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-Associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.",

keywords = "CD163, PD-L1, Pigmented epithelioid melanocytoma, Prognosis, Tumor-Associated macrophages",

author = "Kentaro Ohuchi and Taku Fujimura and Yumi Kambayashi and Hisayuki Tono and Eika Ohtake and Akira Hashimoto and Setsuya Aiba",

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AU - Ohuchi, Kentaro

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Tono, Hisayuki

AU - Ohtake, Eika

AU - Hashimoto, Akira

AU - Aiba, Setsuya

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Pigmented epithelioid melanocytoma (PEM), also known as an animal-Type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-Associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.

AB - Pigmented epithelioid melanocytoma (PEM), also known as an animal-Type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-Associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.

KW - CD163

KW - PD-L1

KW - Pigmented epithelioid melanocytoma

KW - Prognosis

KW - Tumor-Associated macrophages

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Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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